We have just published a new guide which outlines the dangers and side effects of splenda, among other topics related to sweeteners.
One interesting point made in the article is that the actual amount of Splenda that one ingests on a daily, weekly, monthly basis matters a great deal:
"The manufacturer of Splenda claims that very little sucralose gets absorbed into our bloodstream, and the amount that is absorbed is excreted through our urine. It's easy to assume from this claim that there is a 100% recovery rate of sucralose, either through urine or feces, but this study found that total recovery rate for a normal dose of sucralose (1mg/kg) was 92.8% and for a high dose (10mg/kg) was 96.7%, which means that approximately 3.3% to 7.2% of the sucralose remained in the body after five days.
If you had Splenda once, chances are that the tiny amount to remain in your system caused no harm and was eventually excreted. However....
Splenda, and other sucralose-containing products aren't marketed for one-time users, however, but for habitual users. Splenda is for people who want to cut sugar calories out of their sweet foods and drinks. Sucralose in small amounts occasionally is not likely to accumulate, but what happens when a small amount is ingested every day? "